QS-21 Product Description
QS-21 is a water-soluble triterpene saponin purified from the bark of the South American saponaria tree. Globally, the saponin extract QS-21 is currently used in five approved human recombinant protein vaccine products, where it has been shown to be the gold-standard grade adjuvant molecule that induces a favorable immune response; there are also dozens of vaccine products containing the adjuvant molecule under development. However, since the substance is a natural product, it has been facing problems such as restricted places of origin and extremely difficult to control quality stability, which have limited its application in China. Jicang guarantees the source of natural materials in many ways to meet the R&D and production needs of domestic enterprises. Jicang's QS-21 is strictly screened from the bark raw material, and then purified under strict quality control at each step to ensure that Jicang's QS-21 meets the pharmacopoeial quality standards.
Mechanism of action
QS-21 possesses a range of cross-activating abilities, especially targeting key cell populations that play a role in the acquired immune response, thus inducing the production of strong antibodies and cell-mediated immune responses, thereby enhancing the effectiveness of the vaccine. As a semi-hydrophilic surfactant, QS-21 stimulates the activation of antigen phagocytosis, processing, and cross-presentation via MHC in antigen-presenting cells, as well as the direct activation of T-cells via CD2 receptor stimulation, which leads to the production of Th1-associated cytokine secretion.
Application Examples
QS-21 also has a wide range of applications, as studies in animal models have shown that it can enhance the immunogenicity of a wide range of antigens, including proteins, glycoproteins, and polysaccharides. It is currently used in a range of immunotherapeutic vaccines, such as those against tumors (melanoma, brain tumors, breast, uterine and lung cancer), neurodegenerative diseases, and infectious diseases.
Human vaccines must use high quality QS-21, which can be used alone or in as part of a formulation. For example:
1) by forming formulations with liposomes or bisphospholipids; 2) by neutralizing surface activity and thus improving tolerance; 3) by enhancing stability in alkaline environments and maintaining high adjuvant properties in the final vaccine product.
Suggested Dosage: Mouse 10-20μg; Guinea pig 25-50μg; Rabbit/Monkey: 50-100μg.
Product Information:
Product Name: QS-21
Product Code: GC07004
Grade: GLP grade, GMP grade
Packing specification: 5mg/vial, 100mg/vial (customization available)